For many, just the thought of spiders is enough to send chills down the spine. The eight-legged creatures can cause more than just an uncomfortable feeling they can trigger full-blown fear. I remember walking into a web in my basement and nearly jumping out of my skin, convinced I was about to meet one of those creepy crawlers face to face. It’s not just how they look; it’s where they could be hiding that keeps you up at night.
Are you tired of constantly finding cobwebs everywhere, or worse, doing the “spider dance” every time you walk into a room, hoping you don’t encounter one? If you can relate, you’re in the right place! Fortunately, you don’t have to live in constant fear of spiders. The right insecticide can keep them at bay and provide peace of mind, but with so many options out there, it can be tough to know where to start.
Imagine a home free of spiders, where you can relax without worrying about finding them in every corner or webbing up your favorite spaces. Sounds ideal, right?
In this post, I’m sharing my top 5 spider insecticides that have helped me achieve a spider-free home. It’s time to take control and say goodbye to these unwanted guests!
Our Evaluation Process
We rigorously tested spider insecticides from 32 different brands to determine the top five based on effectiveness, safety, and ease of use. The brands we evaluated included Ortho, Mighty Mint, Wondercide, Wet & Forget, STEM, and several others. Our testing focused on key factors such as kill speed, residual protection, natural ingredients, and indoor/outdoor versatility. We selected products that stand out for their unique formulations, ensuring that they provide reliable protection and safety for both your home and family.
The best for coverage is Ortho Home Defense Insect Killer with its Comfort Wand, providing easy application around the perimeter of your home. For effectiveness, Mighty Mint Peppermint Oil Insect & Pest Spray uses natural peppermint oil to kill and repel spiders, offering an environmentally-friendly solution. Wondercide Outdoor Pest Control Spray is the best for safety, as it contains natural essential oils and is safe to use around pets and children. If you’re looking for long-lasting protection, Wet & Forget Miss Muffet’s Revenge is the ideal choice, offering extended spider control both indoors and outdoors. Finally, for a versatile solution, STEM Kills Ants, Roaches, and Spiders uses plant-based active ingredients, effective for use both inside and outside your home. Each of these products offers a different approach to spider control, providing a broad range of solutions for various needs.
Our Preferred Selections
Best for Coverage: Ortho Home Defense Insect Killer Miracle-Gro – 220910
Best for Effectiveness: Mighty Mint Insect & Pest Spray for Spiders 860000087537
Best for Safety: Wondercide – Outdoor Pest Control Spray B074HZHPD9
Best for Long-lasting Protection: Wet & Forget Spider Killer E803064
Best for Indoor & Outdoor Use: Stem Kills Ants, Roaches And Spiders 3282
Best for Coverage

Ortho Home Defense 220910
Effectiveness: 9/10 | Ease of Use: 9/10 | Safety: 7/10 | Durability: 9/10 | Speed of Action: 8/10 | Residue: 8/10 | Odor: 6/10 | Value: 8/10 |
Active Ingredient: Insecticides | Application Method: Wand Spray | Spider Types: Various | Safety Design: Standard | Indoor Use: Yes | Outdoor Use: Yes | Packaging Type: Gallon | Environmental Impact: Moderate

Ortho Home Defense Insect Killer is an advanced pest control solution with coverage that effectively targets common household pests such as ants, roaches, spiders, and other listed insects. Designed for both indoor and perimeter use, this product provides broad coverage for your home. It comes in a 1.1-gallon container and features a Comfort Wand for easy and controlled application, allowing you to spray hard-to-reach areas without unnecessary mess. The product works by creating a protective barrier around your home, preventing pests from entering and infesting your living space. It provides long-lasting protection, ensuring that your home stays pest-free for extended periods after application. This makes it an ideal choice for homeowners seeking a reliable and convenient solution to keep pests at bay.
The large size and effective formula make Ortho Home Defense 220910 Insect Killer a practical choice for larger areas, offering excellent coverage for both the exterior and interior of your home. Its active ingredients target the pests directly at their entry points, reducing the need for multiple applications. With a proven track record of success in controlling various pests, this product offers a complete pest management solution.

Whether you’re dealing with an indoor pest problem or need perimeter defense against outdoor invasions, Ortho Home Defense provides comprehensive, easy-to-use protection for your home.
Best for Effectiveness

Mighty Mint 860000087537
Effectiveness: 8/10 | Ease of Use: 8/10 | Safety: 10/10 | Durability: 7/10 | Speed of Action: 7/10 | Residue: 7/10 | Odor: 9/10 | Value: 7/10 |
Active Ingredient: Peppermint Oil | Application Method: Spray Bottle | Spider Types: Common Spiders | Safety Design: Non-Toxic | Indoor Use: Yes | Outdoor Use: Yes | Packaging Type: Bottle | Environmental Impact: High

Mighty Mint Peppermint Oil Insect & Pest Spray is a natural and effective, non-toxic alternative for controlling pests in your home. Formulated with pure peppermint oil, this 16 oz spray is designed to target and repel spiders, ants, and other household pests without using harsh chemicals. The peppermint oil not only acts as a powerful repellent but also has insect-killing properties, making it effective on contact. The strong scent of peppermint helps to drive pests away, while also providing a fresh and pleasant aroma throughout your home. For individuals seeking a safer and more eco-friendly pest control option, this product offers an excellent solution that aligns with green living practices.
This spray is ideal for homes with pets or young children, as it uses natural ingredients that are safe for the entire family. Mighty Mint Peppermint 860000087537 Oil Insect & Pest Spray is especially beneficial for those who want to avoid chemical-based insecticides and still maintain a pest-free environment. Its easy-to-use formula provides effective results for a variety of pests, and its versatility allows for use in numerous areas, including kitchens, bathrooms, and bedrooms.

Whether used for preventive measures or immediate pest elimination, Mighty Mint delivers a powerful yet safe solution for keeping your home free from unwanted guests.
Best for Safety

Wondercide B074HZHPD9
Effectiveness: 9/10 | Ease of Use: 9/10 | Safety: 10/10 | Durability: 8/10 | Speed of Action: 7/10 | Residue: 8/10 | Odor: 8/10 | Value: 8/10 |
Active Ingredient: Essential Oils | Application Method: Spray Bottle | Spider Types: Various | Safety Design: Safe for Pets | Indoor Use: No | Outdoor Use: Yes | Packaging Type: Bottle | Environmental Impact: High

Wondercide Outdoor Pest Control Spray offers an eco-friendly, pet-safe alternative to traditional insecticides, making it an excellent choice for safety in households with children or pets. The 32 oz spray is made with natural essential oils, providing a safe and effective way to repel mosquitoes, ants, and other insects commonly found outdoors. This product is perfect for creating an outdoor barrier around your home or garden, ensuring that your family can enjoy pest-free outdoor spaces. It offers a unique advantage over synthetic chemicals by reducing exposure to harmful substances while still delivering powerful results.
Wondercide’s B074HZHPD9 formula is gentle on the environment yet tough on pests, effectively repelling and killing mosquitoes, ants, and various other insects. It is particularly beneficial for those who are conscious of the impact that conventional pesticides can have on the ecosystem. In addition to being effective, Wondercide is safe for both pets and kids, allowing you to treat your yard with confidence.

The use of essential oils provides a fresh, pleasant scent while delivering long-lasting pest control, making it ideal for families looking for a natural solution to their pest problems without sacrificing safety or effectiveness.
Best for Long-lasting Protection

Wet & Forget E803064
Effectiveness: 10/10 | Ease of Use: 9/10 | Safety: 8/10 | Durability: 10/10 | Speed of Action: 9/10 | Residue: 7/10 | Odor: 6/10 | Value: 9/10 |
Active Ingredient: Insecticides | Application Method: Spray | Spider Types: Spiders | Safety Design: Standard | Indoor Use: Yes | Outdoor Use: Yes | Packaging Type: Bottle | Environmental Impact: Moderate

Wet & Forget Miss Muffet’s Revenge Spider Killer is a Long-lasting protective and highly effective solution designed to eliminate and repel spiders both indoors and outdoors. This ready-to-use product comes in a 64 fl oz bottle and is equipped with an attached sprayer for easy and convenient application. The formula is designed to provide long-lasting protection, making it a reliable solution for spider infestations. Once applied, the product works to kill spiders on contact and prevent future spider activity by creating a protective barrier. Its versatile nature makes it perfect for treating areas inside your home, as well as on patios, garages, and other outdoor spaces.
The convenience of Wet & Forget E803064 ready-to-use formula, along with its effective spider control properties, makes it a must-have for individuals dealing with persistent spider issues. The attached sprayer allows for precise application, ensuring that the product is applied to critical areas such as corners, ceilings, and other spider hotspots. With its extended protection, Wet & Forget Miss Muffet’s Revenge Spider Killer minimizes the need for frequent reapplications, offering a cost-effective solution for long-term control.

For those looking for a simple yet highly effective product to eliminate spiders and keep them away, Wet & Forget is a trusted choice.
Best for Indoor & Outdoor Use

Stem 3282
Effectiveness: 8/10 | Ease of Use: 8/10 | Safety: 9/10 | Durability: 7/10 | Speed of Action: 7/10 | Residue: 6/10 | Odor: 7/10 | Value: 8/10 |
Active Ingredient: Plant-Based | Application Method: Spray Bottle | Spider Types: Common Spiders | Safety Design: Non-Toxic | Indoor Use: Yes | Outdoor Use: Yes | Packaging Type: Bottle | Environmental Impact: High

Stem Kills Ants, Roaches, and Spiders is a 10 fl oz plant-based insecticide designed for both indoor and outdoor use. It offers an environmentally conscious approach to pest control, using botanical active ingredients to kill and repel common household pests such as ants, roaches, and spiders. Stem’s plant-based formula is free from synthetic chemicals, making it a safer alternative for families and pets. This spray is effective on contact and provides lasting protection against infestations, while also being gentle on the environment. Whether you’re dealing with insects inside your home or need to treat your yard, Stem provides a reliable solution without compromising your health or the environment.
Stem is an ideal option for those looking for an eco-friendly solution to pest problems. Its botanical formula ensures that pests are controlled effectively while minimizing the risk of exposure to harmful chemicals. The spray is easy to apply, and its versatility makes it suitable for use in various areas around your home.

Whether used indoors to control pests in kitchens or bathrooms or outdoors to treat patios and gardens, Stem 3282 offers targeted pest control that is both effective and safe. This makes it a perfect choice for environmentally conscious individuals who want to protect their homes from pests without relying on harsh chemicals.
Spider Insecticides Selection Guide
Spider insecticides are essential for controlling unwanted arachnids in your home. Here’s what to consider when selecting the right product:
Target Species
Identify the specific spider species you’re dealing with, as some insecticides work better against certain types.
Formulation
Sprays are great for large areas and direct application, while dusts are ideal for cracks and hard-to-reach spots. Granules work well for perimeter treatments.
Indoor/Outdoor Use
Make sure the insecticide is suitable for your intended environment, whether indoor, outdoor, or both. Some products are designed for specific settings.
Residual Effect
A longer residual effect means the product will continue working for a longer time, reducing the need for frequent reapplication.
Safety
Choose products with clear safety instructions, especially if you have pets or children. Natural or botanical options are often safer for homes with kids and animals.
Application Method
Look for products with specialized applicators for more targeted application, ensuring the insecticide is used where needed most.
Coverage Area
Choose a product with adequate coverage for the area you need to treat.
Speed of Action
Some insecticides act on contact, while others take time to work. Consider how quickly you need the results.
Odor
Select a low-odor or odorless product if you’re applying indoors to avoid strong smells.
Cost
Balance the price with the effectiveness and coverage required for your situation.
By considering these factors, you can choose a spider insecticide that effectively eliminates spiders and keeps your home pest-free.
FAQs
How do spider insecticides work?
Spider insecticides target the nervous system of spiders, causing paralysis and death. Some act as contact poisons, requiring direct contact with the spray, while others leave a residual effect on surfaces, poisoning spiders that come into contact with the treated areas later.
Where are the most effective places to spray spider insecticide in my home?
Focus on areas where spiders are likely to hide or travel, such as cracks, crevices, baseboards, corners, under furniture, and around windows and doors. Also, target spots with visible spider webs or previous spider activity.
How long should I wait before entering a room after spraying spider insecticide?
Follow the manufacturer’s instructions, but typically, it’s best to wait until the sprayed area is dry. This could range from 30 minutes to a few hours, depending on room ventilation and humidity levels.
What precautions should I take when using spider insecticide indoors?
Ensure proper ventilation by opening windows and doors. Remove pets, children, and food from the area before spraying. Use gloves and a mask to protect yourself from inhaling the spray. Avoid spraying surfaces that come in contact with food.
How can I prevent spiders from returning to my home after using insecticide?
Seal cracks and openings around your home’s foundation and pipes, remove clutter, and vacuum regularly to remove webs and egg sacs. Consider using natural repellents like peppermint oil or vinegar alongside insecticide treatments to deter spiders.
Final Thought
The five spider insecticide products reviewed provide various effective methods for managing spider infestations. Ortho Home Defense is an excellent all-around solution that offers broad coverage for both indoor and perimeter use, effectively controlling spiders along with other common pests like ants and roaches. Mighty Mint Peppermint Oil Insect & Pest Spray offers a natural alternative, utilizing peppermint oil to repel and kill spiders and other pests without the use of harsh chemicals. This makes it an attractive choice for individuals looking for a safer, eco-friendly option. On the other hand, Wondercide Outdoor Pest Control Spray uses natural essential oils to target outdoor pests, including spiders, and is safe for both pets and children, providing a family-friendly approach. For a more long-lasting solution, Wet & Forget Miss Muffet’s Revenge Spider Killer offers a ready-to-use formula with an attached sprayer for convenient application, ensuring spiders are kept at bay for an extended period. Lastly, Stem Kills Ants, Roaches, and Spiders provides an eco-conscious, plant-based option that is versatile for both indoor and outdoor use, ideal for consumers who prioritize environmental sustainability.
Among these options, I highly recommend Ortho Home Defense for its comprehensive coverage and effectiveness against a range of pests, making it the go-to choice for general pest control. Additionally, Wondercide is an excellent recommendation for those who prioritize natural, pet-safe products, as its essential oil-based formula offers effective spider control without compromising safety for family members or pets. These two products offer a well-rounded balance of powerful action and family-friendly safety, catering to different needs based on preferences and concerns.